David Julius, PhD

Professor and Chair
Physiology
+1 415 476-0431

Our group is interested in understanding how sensory systems enable us to perceive our world. In one aspect of our research, we exploit the power of natural products to elucidate molecular mechanisms of touch and pain sensation. For example, we have asked how capsaicin, the main pungent ingredient in "hot" chili peppers, elicits burning pain, and how menthol, the cooling agent in mint leaves, evokes an icy cool sensation. Using these and other agents as pharmacological probes, we have identified ion channels on sensory nerve fibers that are activated by heat, cold, or chemical irritants, providing molecular insight into the process of thermosensation, pain, and itch. With the aid of genetic, electrophysiological, structural, and behavioral methods, we are asking how these ion channels are modulated in response to tumor growth, infection, or other forms of injury that produce inflammation and pain hypersensitivity. These basic scientific studies are helping to lay a foundation for the discovery and development of novel analgesic drugs.

Publications: 

Allosteric regulation of TRPV1 by the inflammatory lipid LPA.

bioRxiv : the preprint server for biology

Arnold WR, Julius D, Cheng Y

Gut enterochromaffin cells drive visceral pain and anxiety.

Nature

Bayrer JR, Castro J, Venkataraman A, Touhara KK, Rossen ND, Morrie RD, Maddern J, Hendry A, Braverman KN, Garcia-Caraballo S, Schober G, Brizuela M, Castro Navarro FM, Bueno-Silva C, Ingraham HA, Brierley SM, Julius D

Sensory TRP Channels in Three Dimensions.

Annual review of biochemistry

Diver MM, King JVL, Julius D, Cheng Y

Irritant-evoked activation and calcium modulation of the TRPA1 receptor.

Nature

Zhao J, Lin King JV, Paulsen CE, Cheng Y, Julius D

Structural insights into TRPM8 inhibition and desensitization.

Science (New York, N.Y.)

Diver MM, Cheng Y, Julius D

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain.

Cell

Lin King JV, Emrick JJ, Kelly MJS, Herzig V, King GF, Medzihradszky KF, Julius D

Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment.

Current opinion in structural biology

Autzen HE, Julius D, Cheng Y