Koki Tohara, PhD | Julius Lab at UCSF

Robert A. Swanson Family Fellow of the Damon Runyon Cancer Research Foundation

Postdoctoral Scholar

Publications

Topological segregation of stress sensors along the gut crypt-villus axis.

Nature

Touhara KK, Rossen ND, Deng F, Castro J, Harrington AM, Chu T, Garcia-Caraballo S, Brizuela M, O'Donnell T, Xu J, Cil O, Brierley SM, Li Y, Julius D

Endogenous opioid signalling regulates spinal ependymal cell proliferation.

Nature

Yue WWS, Touhara KK, Toma K, Duan X, Julius D

Gut enterochromaffin cells drive visceral pain and anxiety.

Nature

Bayrer JR, Castro J, Venkataraman A, Touhara KK, Rossen ND, Morrie RD, Maddern J, Hendry A, Braverman KN, Garcia-Caraballo S, Schober G, Brizuela M, Castro Navarro FM, Bueno-Silva C, Ingraham HA, Brierley SM, Julius D

State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides.

Cell

Dai SA, Hu Q, Gao R, Blythe EE, Touhara KK, Peacock H, Zhang Z, von Zastrow M, Suga H, Shokat KM

Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels.

eLife

Niu Y, Tao X, Touhara KK, MacKinnon R

Structural identification of a hotspot on CFTR for potentiation.

Science (New York, N.Y.)

Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J

Molecular basis of signaling specificity between GIRK channels and GPCRs.

eLife

Touhara KK, MacKinnon R

Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells.

eLife

Del Mármol JI, Touhara KK, Croft G, MacKinnon R

Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels.

eLife

Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R

The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers.

eLife

Touhara KK, Wang W, MacKinnon R

Structural basis for reversible phosphorolysis and hydrolysis reactions of 2-O-a-glucosylglycerol phosphorylase.

The Journal of biological chemistry

Touhara KK, Nihira T, Kitaoka M, Nakai H, Fushinobu S

Structural and biochemical analyses of glycoside hydrolase family 26 ß-mannanase from a symbiotic protist of the termite Reticulitermes speratus.

The Journal of biological chemistry

Tsukagoshi H, Nakamura A, Ishida T, Touhara KK, Otagiri M, Moriya S, Samejima M, Igarashi K, Fushinobu S, Kitamoto K, Arioka M